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La enfermedad de Creutzfeldt-Jakob y la transfusión de sangre
T F Esmonde1, R G Will, J M Slattery
1Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.
Lancet (London, England)
|January 23, 1993
Resumen
Es poco probable que las transfusiones de sangre sean un factor de riesgo importante para la enfermedad de Creutzfeldt-Jakob (ECJ). Los datos de vigilancia no mostraron un aumento en la frecuencia de transfusiones o donaciones de sangre en pacientes con ECJ en comparación con los controles.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Epidemiología La epidemiología.
- Salud Pública La salud pública.
Sus antecedentes:
- La enfermedad de Creutzfeldt-Jakob (ECJ) es un trastorno neurodegenerativo raro y fatal.
- Comprender las posibles vías de transmisión, como la transfusión de sangre, es crucial para la salud pública.
- Anteriormente existían preocupaciones con respecto a la transmisión de la enfermedad priónica a través de productos sanguíneos.
Objetivo del estudio:
- Para investigar la asociación entre la historia de transfusiones de sangre y la enfermedad de Creutzfeldt-Jakob (ECJ) en el Reino Unido.
- Para comparar la frecuencia de la transfusión de sangre y la donación en pacientes con ECJ con controles de edad y sexo.
- Para analizar las características clínicas de la ECJ en pacientes con antecedentes de transfusiones de sangre.
Principales métodos:
- Vigilancia epidemiológica de casos definitivos y probables de enfermedad de Creutzfeldt-Jakob (ECJ) en el Reino Unido.
- Análisis de casos y controles que compara la transfusión de sangre y la historia de donación en pacientes con ECJ frente a controles.
- Revisión de datos clínicos para pacientes con antecedentes de transfusión de sangre.
Principales resultados:
- De los 202 casos de ECJ, 21 tenían antecedentes de transfusiones de sangre y 29 habían donado sangre.
- La frecuencia de la transfusión o donación de sangre no difería significativamente entre los pacientes con ECJ y los controles.
- Las características clínicas en los receptores de transfusiones fueron consistentes con la ECJ clásica, distinta de la variante de ECJ vinculada a la hormona del crecimiento humano.
Conclusiones:
- La evidencia actual no apoya la transfusión de sangre como un factor de riesgo importante para la enfermedad de Creutzfeldt-Jakob (ECJ).
- El estudio proporciona tranquilidad con respecto a la seguridad de la transfusión de sangre en relación con la transmisión de ECJ.
- Es posible que se justifique una mayor vigilancia e investigación para rutas de transmisión raras o emergentes.
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