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Relajación de la impronta genética del factor de crecimiento II parecido a la insulina implicada en el tumor de Wilms
1Department of Biochemistry, University of Otago, Dunedin, New Zealand.
Nature
|April 22, 1993
Resumen
Los defectos de impresión genómica, específicamente en el gen del factor de crecimiento similar a la insulina II (IGF2), están relacionados con el desarrollo del tumor de Wilms. La relajación de la impresión, que conduce a la expresión bialélica de IGF2, sugiere un nuevo mecanismo de cáncer.
Área de la Ciencia:
- Genética La genética.
- Biología del desarrollo Biología del desarrollo.
- Oncología Oncología.
Sus antecedentes:
- La impresión genómica es crucial en el desarrollo embrionario y está implicada en cánceres.
- La pérdida de heterocigosidad en el cromosoma 11p15 y la isodisomía paterna sugieren el papel de los genes impresos en el tumor de Wilms y el síndrome de Beckwith-Wiedemann.
Objetivo del estudio:
- Investigar el papel del gen del factor de crecimiento similar a la insulina II (IGF2) en el inicio del tumor de Wilms.
- Para determinar si la impresión alterada de IGF2 contribuye a la tumorigénesis de Wilms.
Principales métodos:
- Análisis de la expresión génica de IGF2 en tejidos fetales humanos.
- Examen de los patrones de expresión de IGF2 en muestras de tumores de Wilms.
Principales resultados:
- El gen IGF2 se expresa paternalmente en el tejido fetal humano normal.
- Los tumores de Wilms exhiben expresión bialélica del gen IGF2, lo que indica una pérdida de impresión.
- Esta relajación de la impresión se observa por primera vez en el inicio de la enfermedad.
Conclusiones:
- La relajación de la impresión genómica, específicamente la expresión bialélica de IGF2, es un mecanismo potencial en el desarrollo del tumor de Wilms.
- Este hallazgo sugiere una nueva vía genética que contribuye a la etiología del cáncer.
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