Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Carbon Skeletons01:12

Carbon Skeletons

84.6K
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
84.6K
Gross Anatomy of Bone01:17

Gross Anatomy of Bone

14.3K
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
14.3K
Compact Bone01:27

Compact Bone

22.4K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
22.4K
Virtual Work for a System of Connected Rigid Bodies01:06

Virtual Work for a System of Connected Rigid Bodies

858
Virtual work is a powerful method used to solve problems involving several connected rigid bodies. When the system is in equilibrium, virtual work is zero. This allows the calculation of the resulting forces when a system undergoes a virtual displacement. When attempting to analyze such a system, first, use a free-body diagram, where an independent coordinate represents the configuration of the links, and mark its deflected position resulting from the positive virtual displacement.
Next,...
858
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

5.7K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
5.7K
Steel Manufacturing01:26

Steel Manufacturing

1.5K
Steel manufacturing is a multi-stage process that begins by smelting iron ore into cast iron in a blast furnace. This initial stage involves layering iron ore with coke, a type of fuel, and crushed limestone within the furnace. The coke is ignited with a high volume of air, leading to the creation of carbon monoxide, which acts to reduce the iron ore to pure iron.
During this smelting process, limestone plays a crucial role by forming slag. Slag captures impurities within the molten iron, such...
1.5K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Deep learning image enhancement algorithms in PET/CT imaging: a phantom and sarcoma patient radiomic evaluation.

European journal of nuclear medicine and molecular imaging·2025
Same author

Complex small-world regulatory networks emerge from the 3D organisation of the human genome.

Nature communications·2021
Same author

Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up<sup>☆</sup>.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Relation of Dietary Factors with Infection and Mortality Rates of COVID-19 across the World.

The journal of nutrition, health & aging·2020

Video Experimental Relacionado

Updated: May 4, 2026

Operation of the Collaborative Composite Manufacturing CCM System
10:09

Operation of the Collaborative Composite Manufacturing CCM System

Published on: October 1, 2019

6.2K

Visualización de fábricas de replicación unidas al nucleoesqueleto.

P Hozák1, A B Hassan, D A Jackson

  • 1Sir William Dunn School of Pathology, University of Oxford, England.

Cell
|April 23, 1993
PubMed
Resumen

La replicación del ADN ocurre en sitios discretos, o "fábricas", unidas a un esqueleto celular. El ADN recién sintetizado aparece inicialmente en estas fábricas antes de extenderse a la cromatina circundante.

Más Videos Relacionados

Pedicle Screw Placement Using an Augmented Reality Head-Mounted Display in a Porcine Model
06:18

Pedicle Screw Placement Using an Augmented Reality Head-Mounted Display in a Porcine Model

Published on: May 24, 2024

3.4K
Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control
05:47

Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control

Published on: August 29, 2025

673

Videos de Experimentos Relacionados

Last Updated: May 4, 2026

Operation of the Collaborative Composite Manufacturing CCM System
10:09

Operation of the Collaborative Composite Manufacturing CCM System

Published on: October 1, 2019

6.2K
Pedicle Screw Placement Using an Augmented Reality Head-Mounted Display in a Porcine Model
06:18

Pedicle Screw Placement Using an Augmented Reality Head-Mounted Display in a Porcine Model

Published on: May 24, 2024

3.4K
Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control
05:47

Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control

Published on: August 29, 2025

673

Área de la Ciencia:

  • Biología celular Biología celular.
  • Biología Molecular Biología Molecular
  • Genética La genética.

Sus antecedentes:

  • La replicación del ADN es esencial para la división celular.
  • La organización espacial de los sitios de replicación del ADN no se entiende completamente.

Objetivo del estudio:

  • Para visualizar y caracterizar los sitios físicos de síntesis de ADN dentro del núcleo.
  • Para investigar la dinámica de la replicación del ADN en estos sitios.

Principales métodos:

  • Las células HeLa fueron encapsuladas en microesferas de agarosa.
  • Los sitios de síntesis de ADN fueron etiquetados con biotina-11-dUTP e inmunolabelados.
  • Se usaron microscopios de luz y electrones para examinar las estructuras nucleares.
  • La cromatina se eliminó parcialmente para visualizar las estructuras subyacentes.

Principales resultados:

  • Se observaron aproximadamente 150 sitios focales de síntesis de ADN por núcleo.
  • Estos sitios contenían ADN polimerasa alfa y antígeno nuclear celular proliferante.
  • La microscopía electrónica reveló cuerpos ovoides discretos unidos a un nucleoesqueleto.
  • La incorporación de biotina ocurrió inicialmente dentro de estos cuerpos ovoides, luego se extendió a la cromatina.

Conclusiones:

  • La replicación del ADN ocurre en fábricas de polimerización fijas unidas a un esqueleto nuclear.
  • La replicación procede a medida que la plantilla de ADN se mueve a través de estas fábricas estacionarias.