El cromosoma 11q13 y la atopia subyacente al eczema atópico
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Updated: Nov 10, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
R Coleman1, R C Trembath, J I Harper
1Department of Dermatology, Hospitals for Sick Children, London, UK.
Lancet (London, England)
|May 1, 1993
Resumen
Este estudio investigó la base genética de la atopia, explorando específicamente el cromosoma 11q13. Los hallazgos sugieren que esta región no alberga un importante locus de susceptibilidad para la enfermedad atópica, pero la influencia materna justifica una mayor investigación.
Área de la Ciencia:
- Genética La genética.
- Inmunología Inmunología.
- Dermatología Dermatología dermatología.
Sus antecedentes:
- La enfermedad respiratoria atópica ha mostrado un vínculo genético con el cromosoma 11q13.
- El eczema atópico es una manifestación común de la atopia.
Objetivo del estudio:
- Para investigar el papel del cromosoma 11q13 en la susceptibilidad a la atopia.
- Para analizar el vínculo genético en familias múltiples con eczema atópico.
Principales métodos:
- Reclutó 95 familias múltiples a través de probantes con eczema atópico activo.
- Realizó análisis de vinculación entre la atopia y los marcadores en el cromosoma 11q13.
- Compartir alelos analizados en pares de hermanos afectados y estratificado por el fenotipo atópico parental.
Principales resultados:
- Los análisis de vinculación excluyeron un importante locus de susceptibilidad para la atopia en 11q13.
- No se observó ninguna desviación significativa en el intercambio de alelos por pares de hermanos afectados.
- Se observó una puntuación lod positiva (0,8) en familias con padres no afectados, lo que sugiere una posible influencia materna.
Conclusiones:
- Es poco probable que el cromosoma 11q13 contenga un locus de mayor susceptibilidad para la atopia.
- La influencia materna en la herencia de la atopia no puede ser excluida y requiere más estudios.
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