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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
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Abolición de la anafilaxis mediante la interrupción dirigida del gen de la cadena alfa del receptor de
D Dombrowicz1, V Flamand, K K Brigman
1Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852.
Cell
|December 3, 1993
Resumen
El receptor de inmunoglobulina E (IgE) de alta afinidad, Fc epsilon RI, es esencial para desencadenar la anafilaxis. Los ratones que carecían de este receptor estaban protegidos de reacciones alérgicas, lo que indica su papel crítico.
Área de la Ciencia:
- Inmunología Inmunología.
- Investigación de Alergias Investigación de Alergias
- La señalización celular.
Sus antecedentes:
- Los mastocitos y los basófilos son actores clave en la anafilaxia, activados por la inmunoglobulina E (IgE) y los alérgenos.
- Estas células expresan múltiples receptores de IgE, incluidos Fc epsilon RI, Fc epsilon RII/CD23 y Mac-2.
- Los roles específicos de estos receptores en el inicio de la anafilaxis in vivo siguen siendo incompletamente entendidos.
Objetivo del estudio:
- Investigar la necesidad del receptor IgE de alta afinidad (Fc epsilon RI) en el desarrollo de la anafilaxia.
- Para determinar la contribución de Fc epsilon RI a las reacciones alérgicas dependientes de IgE in vivo.
Principales métodos:
- Generación de ratones con deficiencia de Fc epsilon RI.
- Evaluación del desarrollo de la anafilaxia en estos ratones genéticamente modificados.
- Comparación de respuestas alérgicas entre ratones con deficiencia de Fc epsilon RI y ratones de tipo salvaje.
Principales resultados:
- Los ratones con deficiencia de Fc epsilon RI mostraron un desarrollo normal y poblaciones de mastocitos.
- Estos ratones eran resistentes tanto a la anafilaxia cutánea como a la sistémica.
- La ausencia de Fc epsilon RI anuló las reacciones anafilácticas dependientes de IgE.
Conclusiones:
- Fc epsilon RI es un receptor crítico y necesario para el inicio de la anafilaxis dependiente de IgE.
- Dirigirse a la función de Fc epsilon RI presenta una estrategia terapéutica potencial para el tratamiento de las alergias, independientemente del tipo de alergeno.
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