Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Tumour-stroma ratio to predict pathological response to neo-adjuvant treatment in rectal cancer.

Surgical oncology·2022
Same author

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis.

Thrombosis and haemostasis·2018
Same author

Mesh Versus Patch Repair for Epigastric and Umbilical Hernia (MORPHEUS Trial); One-Year Results of a Randomized Controlled Trial.

World journal of surgery·2017
Same author

Long-term outcome of low perianal fistulas treated by fistulotomy: a multicenter study.

International journal of colorectal disease·2014
Same author

Rectovaginal fistula: a new technique and preliminary results using collagen matrix biomesh.

Techniques in coloproctology·2014
Same author

Secondary healing versus midline closure and modified Bascom natal cleft lift for pilonidal sinus disease.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2011
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: Jun 19, 2026

Preparation of Adult Drosophila Eyes for Thin Sectioning and Microscopic Analysis
07:49

Preparation of Adult Drosophila Eyes for Thin Sectioning and Microscopic Analysis

Published on: August 27, 2011

El erizo Drosophila actúa como un morfógeno en el patrón celular.

J Heemskerk1, S DiNardo

  • 1Department of Physiology, Columbia University, New York, New York 10032.

Cell
|February 11, 1994
PubMed
Resumen

Las células engrailed-expressing en embriones de Drosophila actúan como organizadores, controlando el destino celular a través del gen del erizo (hh). La modulación de los niveles de hh sugiere que funciona como un morfógeno dependiente de la concentración.

Más Videos Relacionados

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster
10:10

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Videos de Experimentos Relacionados

Last Updated: Jun 19, 2026

Preparation of Adult Drosophila Eyes for Thin Sectioning and Microscopic Analysis
07:49

Preparation of Adult Drosophila Eyes for Thin Sectioning and Microscopic Analysis

Published on: August 27, 2011

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster
10:10

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • Genética La genética.
  • Biología molecular La biología molecular.

Sus antecedentes:

  • La embriogénesis se basa en regiones organizadoras para modelar los tipos de células.
  • Los mecanismos precisos del patrón segmental en Drosophila son complejos.

Objetivo del estudio:

  • Para investigar las propiedades organizadoras de las células engrailed-expressing en la Drosophila epidermis.
  • Para aclarar el papel del gen del erizo (hh) en la mediación de la diferenciación de tipo celular durante la embriogénesis.

Principales métodos:

  • Análisis de las células engrailed-expresoras en la Drosophila epidermis.
  • Modulación de los niveles de expresión génica del erizo (hh) en embriones.
  • Modelado de la interacción entre las vías de señalización hh y wingless.

Principales resultados:

  • Las células enraizadas que expresan exhiben propiedades organizadoras, influyendo en la diferenciación celular epidérmica.
  • El gen del erizo (hh) media esta función de patronaje.
  • Hedgehog (hh) actúa como un morfógeno, especificando los destinos celulares de una manera dependiente de la concentración.

Conclusiones:

  • Las células que expresan el engrailed son organizadores clave en la Drosophila epidermis.
  • La señalización del erizo (hh) es crucial para establecer la diversidad del tipo de célula segmental.
  • Un modelo que integra la señalización hh y wingless explica el patrón segmental.