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A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
La herencia hormonalmente mediada de las características adquiridas en gerbilles mongoles
M M Clark1, P Karpiuk, B G Galef
1Department of Psychology, McMaster University, Hamilton, Ontario, Canada.
Nature
|August 19, 1993
Resumen
Los fetos de roedores hembras expuestos a hermanos machos en el útero se androgenizan, alterando el comportamiento adulto. Estas madres tienden a producir más hijos varones, transmitiendo el rasgo androgenizado a sus hijas.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Comportamiento animal Comportamiento animal.
- Endocrinología Endocrinología.
Sus antecedentes:
- La posición intrauterina influye en el desarrollo fetal y los fenotipos adultos en roedores.
- La exposición a los andrógenos en el útero puede conducir a cambios significativos en la morfología y el comportamiento.
- Estudios previos indican efectos específicos por sexo del posicionamiento intrauterino.
Objetivo del estudio:
- Para investigar el efecto de la posición intrauterina en la relación de sexo de la descendencia en jerbos mongoles.
- Para determinar si las hembras gerbillas adultas expuestas a fetos masculinos en el útero producen camadas diferentes en comparación con las expuestas a fetos femeninos.
- Explorar la herencia transgeneracional de los fenotipos de androgenización.
Principales métodos:
- Comparación de las relaciones sexuales de las hembras adultas de gerbilles mongoles basadas en su propio posicionamiento intrauterino (gestado entre machos y hembras).
- Estudio observacional de los resultados reproductivos del gerbil de Mongolia.
- Análisis de los fenotipos maternos y de la descendencia relacionados con la exposición intrauterina.
Principales resultados:
- Las hembras gerbillas gestadas entre fetos machos produjeron camadas con una proporción significativamente mayor de hijos.
- Las hijas de madres gestadas entre varones tenían más probabilidades de ser androgenizadas in utero.
- Se observó una tendencia a la herencia del fenotipo androgenizado a través de generaciones.
Conclusiones:
- El posicionamiento intrauterino influye en la proporción de sexo de la descendencia en los jerbos.
- La androgenización in utero puede afectar las estrategias reproductivas maternas.
- El estudio sugiere un mecanismo potencial para la herencia de fenotipos del desarrollo en mamíferos.
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