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FGF-4 y BMP-2 tienen efectos opuestos en el crecimiento de las extremidades

L Niswander1, G R Martin

  • 1Department of Anatomy, School of Medicine, University of California, San Francisco 94143.

Nature
|January 7, 1993
PubMed
Resumen

El desarrollo de las extremidades depende de las señales de la cresta ectodérmica apical (AER). El factor de crecimiento de fibroblastos-4 (FGF-4) estimula el crecimiento de los brotes de las extremidades, mientras que la proteína morfogénica ósea-2 (BMP-2) lo inhibe, lo que sugiere funciones AER duales.

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