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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

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Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens.

Parasite immunology·2009
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Distinct expression pattern of IFN-alpha and TNF-alpha in juvenile idiopathic arthritis synovial tissue.

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Cytokine-driven proliferation and differentiation of human naïve, central memory and effector memory CD4+ T cells.

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Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells.

The Journal of experimental medicine·2001
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BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.

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Video Experimental Relacionado

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Identificación de estrategias para la intervención inmune.

A Lanzavecchia1

  • 1Basel Institute for Immunology, Switzerland.

Science (New York, N.Y.)
|May 14, 1993
PubMed
Resumen

La comprensión de las vías de reconocimiento y activación de las células T permite intervenciones en el sistema inmunológico. Este conocimiento ayuda en el desarrollo de vacunas, respuestas antitumorales y en el manejo de enfermedades autoinmunes y rechazo de injerto.

Área de la Ciencia:

  • Inmunología Inmunología.
  • Biología Molecular Biología Molecular
  • Vacunología Vacunología.

Sus antecedentes:

  • Los mecanismos moleculares del reconocimiento de antígenos de células T se comprenden cada vez mejor.
  • Se están definiendo las vías que regulan la activación y especialización de las células T.

Objetivo del estudio:

  • Aprovechar los recientes avances en la biología de las células T para estrategias terapéuticas.
  • Explorar intervenciones para el desarrollo de vacunas, la inmunoterapia contra el cáncer y el manejo de trasplantes / enfermedades autoinmunes.

Principales métodos:

  • Análisis molecular del reconocimiento de antígenos de células T.
  • Elucidación de la activación de las células T y las vías funcionales.

Principales resultados:

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  • Comprensión detallada de cómo las células T reconocen los antígenos.
  • Recorridos definidos que controlan la activación y especialización de las células T.

Conclusiones:

  • El conocimiento de las vías de las células T permite intervenciones específicas del sistema inmunológico.
  • Se pueden diseñar estrategias para vacunas, inmunidad tumoral, tolerancia al injerto y control de enfermedades autoinmunes.