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Chlamydia pneumoniae (TWAR, por sus siglas en inglés) en la aterosclerosis de la arteria carótida
J T Grayston1, C C Kuo, A S Coulson
1Department of Epidemiology, University of Washington, Seattle 98195-7236, USA.
Circulation
|December 15, 1995
Resumen
Las bacterias de Chlamydia pneumoniae se detectaron con frecuencia en los tejidos de aterosclerosis de la arteria carótida de pacientes sometidos a endarterectomía. Se necesita más investigación para explorar el papel potencial de esta infección en la enfermedad de la arteria carótida.
Área de la Ciencia:
- Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular Investigación cardiovascular
- Patología de Enfermedades Infecciosas Patología de Enfermedades Infecciosas
- Microbiología Microbiología.
Sus antecedentes:
- La Chlamydia pneumoniae se ha identificado en lesiones ateroscleróticas de la aorta y las arterias coronarias.
- Un estudio previo de seroepidemiología indicó una mayor prevalencia de anticuerpos de C. pneumoniae en individuos con un espesamiento significativo de la pared de la arteria carótida en comparación con los controles.
Objetivo del estudio:
- Para investigar la presencia de Chlamydia pneumoniae en muestras de endarterectomía carotídea.
- Para determinar la asociación entre C. pneumoniae y la aterosclerosis de la arteria carótida.
Principales métodos:
- La inmunocitoquímica (ICC) y la reacción en cadena de la polimerasa (PCR) se utilizaron para detectar C. pneumoniae en tejidos de endarterectomía carotídea recién congelados y fijados con formalina.
- También se examinaron los tejidos fijados en formalina y parafina de 56 pacientes utilizando ICC.
- El tejido normal de la arteria carótida de seis pacientes sirvió como grupo de control.
Principales resultados:
- Todos los cinco especímenes de endarterectomía carotídea recién congelados y fijados en formalina dieron positivo para C. pneumoniae por ICC, con PCR confirmando su presencia en tres.
- El análisis del ICC de 56 tejidos de archivo reveló C. pneumoniae en 32 especímenes.
- Trece secciones de tejido de la arteria carótida normal dieron negativo para C. pneumoniae.
Conclusiones:
- Los organismos de Chlamydia pneumoniae están frecuentemente presentes en lesiones ateroscleróticas carótidas avanzadas de pacientes sometidos a endarterectomía.
- Estos hallazgos sugieren un potencial papel causal o patogénico para C. pneumoniae en la aterosclerosis de la arteria carótida, lo que justifica una mayor investigación.
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