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Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

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El entrenamiento físico mejora la función endotelial en pacientes con insuficiencia cardíaca crónica.

B Hornig¹, V Maier, H Drexler

¹Med Klinik III, University of Freiburg, Germany.

|January 15, 1996

Resumen

El entrenamiento físico mejoró la dilatación dependiente del flujo (FDD) en pacientes con insuficiencia cardíaca crónica al aumentar la liberación de óxido nítrico del endotelio. Esta intervención puede ayudar a restaurar la función vascular en la insuficiencia cardíaca.

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Área de la Ciencia:

Investigaciones Cardiovasculares Investigación Cardiovascular Investigaciones Cardiovasculares
Biología Vascular Biología Vascular
Fisiología del ejercicio Fisiología del ejercicio

Sus antecedentes:

La insuficiencia cardíaca crónica (ICC) está relacionada con la disfunción endotelial, específicamente la dilatación dependiente del flujo mediada por el endotelio (FDD).
La función endotelial es crucial para regular la perfusión tisular y el cumplimiento arterial, por lo que las intervenciones para la disfunción son imperativas.

Objetivo del estudio:

Investigar el potencial del entrenamiento físico para restaurar la FDD en pacientes con insuficiencia cardíaca congestiva.
Para comparar FDD en pacientes con CHF y sujetos sanos de la misma edad.

Principales métodos:

Se utilizó ultrasonido de alta resolución para medir el diámetro de la arteria radial en 12 pacientes con FCH y 7 controles.
FDD evaluado al inicio, durante la hiperemia reactiva y después de la administración de nitroprussida de sodio.
Se determinó el papel del óxido nítrico (NO) mediante el uso de NG-monometil-L-arginina (L-NMMA) para inhibir la síntesis de NO y se repitieron las mediciones después de 4 semanas de entrenamiento diario de agarre.

Principales resultados:

La FDD se deterioró significativamente en pacientes con CHF en comparación con sujetos normales.
L-NMMA atenuado FDD, lo que confirma la participación de la liberación de NO endotelial.
Cuatro semanas de entrenamiento físico restauraron la FDD en pacientes con CHF, con un aumento notable en el componente NO-dependiente de la FDD.

Conclusiones:

El entrenamiento físico restaura efectivamente la FDD en pacientes que sufren de insuficiencia cardíaca crónica.
La liberación endotelial mejorada de óxido nítrico es un mecanismo probable que subyace a los efectos beneficiosos del entrenamiento físico en la FDD en CHF.