Video Experimental Relacionado

Updated: Jul 23, 2026

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

DPC4, un gen supresor de tumores candidato en el cromosoma humano 18q21.11.1

S A Hahn¹, M Schutte, A T Hoque

¹Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Science (New York, N.Y.)

|January 19, 1996

Resumen

Los investigadores identificaron el DPC4 como un potencial gen supresor de tumores. La inactivación de este gen puede contribuir al desarrollo del cáncer de páncreas, ofreciendo nuevos conocimientos sobre la genética del cáncer.

Área de la Ciencia:

Oncología Oncología.
Biología Molecular Biología Molecular
Genética La genética.

Sus antecedentes:

Los carcinomas pancreáticos con frecuencia exhiben pérdida alélica en el cromosoma 18q, lo que sugiere la presencia de genes supresores de tumores en esta región.
La identificación de genes específicos responsables de la supresión tumoral es crucial para comprender el desarrollo del cáncer.

Objetivo del estudio:

Para identificar genes supresores de tumores candidatos en el cromosoma 18q.
Para investigar el papel del gen DPC4 en el cáncer de páncreas.

Principales métodos:

Análisis de un panel de carcinomas pancreáticos para las deleciones homocigotas a 18q.
Secuenciación de genes candidatos para identificar mutaciones.
Comparación de la secuencia DPC4 con genes conocidos de la vía de señalización.

Principales resultados:

Se encontraron deleciones homocigotas en 18q21.1 en 25 de los 84 tumores.
El gen DPC4, ubicado en 18q21.1, fue identificado como un candidato clave.
Se encontraron mutaciones potencialmente inactivadoras en DPC4 en 6 de los 27 tumores sin deleciones homocigóticas.

Conclusiones:

DPC4 se identifica como un gen supresor de tumores candidato.
La inactivación de DPC4 puede desempeñar un papel importante en el cáncer de páncreas.
Se necesita más investigación para explorar el papel de DPC4 en otros tipos de cáncer en humanos.

Más Videos Relacionados

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

Videos de Conceptos Relacionados

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Loss of Tumor Suppressor Gene Functions

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Loss of Tumor Suppressor Gene Functions

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...