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La clonación molecular y la asociación de enfermedades del virus de la hepatitis G: un agente transmisible por
J Linnen1, J Wages, Z Y Zhang-Keck
1Genelabs Technologies, Redwood City, CA 94063, USA.
Science (New York, N.Y.)
|January 26, 1996
Resumen
El virus de la hepatitis G (HGV), un virus de ARN, causa hepatitis aguda y crónica y puede persistir durante años. Este virus transmisible por transfusión tiene una presencia global, incluso en los donantes de sangre estadounidenses.
Área de la Ciencia:
- Virología Virología.
- Hepatología Hepatología.
- Enfermedades infecciosas Enfermedades infecciosas.
Sus antecedentes:
- El virus de la hepatitis G (HGV) es un virus de ARN identificado en pacientes con hepatitis crónica.
- El HGV comparte similitudes genéticas con el virus GB C (GBV-C) y está distantemente relacionado con el virus de la hepatitis C (HCV).
Objetivo del estudio:
- Caracterizar el genoma y las asociaciones clínicas del recién identificado virus de la hepatitis G (VGH).
Principales métodos:
- Secuenciación de clones de ADN complementarios para determinar el genoma completo del HGV.
- Análisis del ARN viral para identificar la poliproteína codificada.
- Revisión de datos clínicos para evaluar la asociación de HGV con la hepatitis y la duración de la viremia.
Principales resultados:
- El genoma completo del HGV tiene 9392 nucleótidos, que codifican una poliproteína de 2873 aminoácidos.
- El HGV está asociado con hepatitis aguda y crónica.
- Se observó viremia persistente que duró hasta 9 años en pacientes infectados.
- El HGV es transmisible por transfusión y tiene una distribución global, encontrándose en donantes de sangre estadounidenses.
Conclusiones:
- El virus de la hepatitis G (HGV) es una causa significativa de la hepatitis viral con un potencial de persistencia a largo plazo.
- La prevalencia mundial y la transmisibilidad por transfusión del HGV resaltan su importancia para la salud pública.
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