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Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae

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Bacteremia con Streptococcus pneumoniae. también. Implicaciones para la terapia y la prevención. El grupo de estudio

J F Plouffe¹, R F Breiman, R R Facklam

¹Department of Internal Medicine, Ohio State University Medical Center, Columbus 43210, USA.

|January 17, 1996

Resumen

La bacteremia por Streptococcus pneumoniae es más común en adultos mayores y afroamericanos, con una creciente resistencia a los antimicrobianos. La vacunación neumocócica y el conocimiento de los patrones de resistencia son cruciales para un tratamiento eficaz.

Área de la Ciencia:

Enfermedades infecciosas Enfermedades infecciosas.
Epidemiología La epidemiología.
Microbiología Microbiología.

Sus antecedentes:

Streptococcus pneumoniae es una de las principales causas de infecciones bacteriémicas.
Comprender la epidemiología y la resistencia a los antimicrobianos de S. pneumoniae es fundamental para la salud pública.

Objetivo del estudio:

Para determinar las tasas de incidencia y mortalidad de Streptococcus pneumoniae bacteremia.
Para identificar los serotipos prevalentes y sus patrones de susceptibilidad antimicrobiana.

Principales métodos:

Determinación de casos prospectivos de S. pneumoniae aislados en sangre desde 1991-1994.
Revisión del gráfico para datos demográficos y pruebas de susceptibilidad antimicrobiana en 499 aislados.

Principales resultados:

Incidencia más alta en adultos ≥65 años (83,0/100,000) y afroamericanos.
Las personas infectadas por el VIH tenían un riesgo 41.8 veces mayor.
La mortalidad general fue del 19%, aumentando con la edad; las cepas resistentes a los medicamentos aumentaron al 24% en 1994.

Conclusiones:

El aumento del uso de la vacuna neumocócica y la conciencia de la resistencia son vitales.
Se recomiendan programas educativos sobre el uso juicioso de antimicrobianos para médicos y pacientes.

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