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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
Published on: January 2, 2017
Minimizar el impacto de Streptococcus pneumoniae resistente a los fármacos (DRSP, por sus siglas en inglés). Una
D B Jernigan1, M S Cetron, R F Breiman
1Childhood and Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Ga 30333, USA.
JAMA
|January 17, 1996
Resumen
El Streptococcus pneumoniae resistente a los medicamentos representa una amenaza significativa para la salud pública. Una nueva estrategia se centra en la vigilancia, la vacunación y el uso juicioso de antibióticos para combatir las infecciones por DRSP.
Área de la Ciencia:
- Salud Pública La salud pública.
- Enfermedades infecciosas Enfermedades infecciosas.
- Microbiología Microbiología.
Sus antecedentes:
- Streptococcus pneumoniae resistente a los medicamentos (DRSP) presenta un desafío creciente debido a una prevalencia e impacto desconocidos.
- Las bajas tasas de vacunación y el uso inadecuado de antimicrobianos exacerban el problema del DRSP.
- Un grupo de trabajo de los Centros para el Control y la Prevención de Enfermedades se estableció en 1994 para abordar el DRSP.
Objetivo del estudio:
- Desarrollar una estrategia integral para la vigilancia, investigación, prevención y control de las infecciones por DRSP.
- Mejorar la comprensión de la magnitud del DRSP, el impacto clínico y los factores de riesgo.
- Promover el aumento de la vacunación neumocócica y el uso juicioso de fármacos antimicrobianos.
Principales métodos:
- Implementación de un sistema electrónico de vigilancia basado en laboratorio (ELBS) para las infecciones invasivas de DRSP.
- Identificación de los factores de riesgo y los resultados asociados con la infección por DRSP.
- Desarrollo de una estrategia nacional para el control de DRSP, incluida la vigilancia reforzada y las intervenciones de salud pública.
Principales resultados:
- La estrategia tiene como objetivo proporcionar datos de prevalencia específicos de la comunidad y oportunos para los neumococos resistentes a los medicamentos.
- Se difundirán las tendencias nacionales, regionales y locales a los médicos para guiar el uso de antimicrobianos y los esfuerzos de vacunación.
- La red ELBS está diseñada para ser adaptable para la vigilancia de otras enfermedades infecciosas.
Conclusiones:
- Se espera que la estrategia propuesta reduzca las complicaciones, secuelas, gastos de atención médica, morbilidad y mortalidad asociados con las infecciones por DRSP.
- La vigilancia reforzada y las intervenciones dirigidas son cruciales para controlar el DRSP.
- La iniciativa tiene como objetivo mejorar las capacidades generales de vigilancia de la salud pública.
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