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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
El gen AUX1 de Arabidopsis: un regulador tipo permeasa del gravitropismo de las raíces
M J Bennett1, A Marchant, H G Green
1Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK.
Science (New York, N.Y.)
|August 16, 1996
Resumen
El gen AUX1 es crucial para el crecimiento de las raíces de las plantas y el gravitropismo, probablemente mediante el transporte de la molécula de señalización de la auxina ácido indol-3-acético. La restauración de la función AUX1 rescata la capacidad de respuesta de la auxina en las raíces de las plantas.
Área de la Ciencia:
- Biología Vegetal Biología Vegetal
- Genética molecular La genética molecular.
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- La hormona vegetal auxina gobierna procesos críticos de desarrollo como la formación de raíces y el gravitropismo.
- Las mutaciones en el gen AUX1 resultan en el crecimiento de raíces resistentes a las auxinas y en un deterioro de la curvatura gravitrópica.
Objetivo del estudio:
- Para investigar la función del gen AUX1 en el desarrollo de las plantas.
- Determinar el papel de AUX1 en el transporte y señalización de las auxinas.
Principales métodos:
- Análisis de los fenotipos aux1 mutantes.
- La clonación de genes y la complementación funcional de raíces transgénicas.
- Examen de los patrones de expresión génica de AUX1.
Principales resultados:
- Las mutaciones del gen AUX1 confieren resistencia a la auxina y eliminan la curvatura gravitrópica de la raíz.
- La similitud de secuencia sugiere que AUX1 transporta una molécula de señalización parecida a un aminoácido, potencialmente ácido indol-3-acético.
- La clonación y la expresión del gen AUX1 restauraron la respuesta a la auxina en las raíces aux1.
- AUX1 se expresa espacialmente en los tejidos apicales de la raíz involucrados en el gravitropismo.
Conclusiones:
- El producto del gen AUX1 es esencial para mediar el transporte de auxinas y la señalización en el desarrollo de las raíces de las plantas.
- AUX1 juega un papel clave en la regulación del gravitropismo de las raíces y la capacidad de respuesta de las auxinas.
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