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Hepatitis no A no B asociada con enfermedad hepática crónica en una unidad de hemodiálisis
Lancet (London, England)
|May 5, 1979
Resumen
El virus de la hepatitis A no estuvo involucrado en un brote de hepatitis no A no B en el Hospital Fulham en 1968-70. Este estudio excluyó el virus de la hepatitis A como causa de hepatitis aguda o crónica en pacientes de la unidad renal.
Área de la Ciencia:
- Hepatología Hepatología.
- Virología Virología.
- Epidemiología La epidemiología.
Sus antecedentes:
- Un brote de hepatitis ocurrió en una unidad renal entre 1968-1970.
- La hepatitis fue HBsAg-negativo (Hepatitis B antígeno de superficie negativo).
- Algunos pacientes posteriormente desarrollaron enfermedad hepática crónica.
Objetivo del estudio:
- Para determinar la etiología del brote de hepatitis HBsAg-negativo.
- Para investigar el papel potencial del virus de la hepatitis A (VHA) en el brote.
- Para evaluar el papel de HAV en la enfermedad hepática crónica subsiguiente.
Principales métodos:
- Pruebas serológicas retrospectivas de anti-HAV (anticuerpo del virus de la hepatitis A) en muestras de suero almacenadas.
- Se analizaron muestras de suero emparejadas de 24 de 29 pacientes infectados.
- Los cambios en los títulos anti-HAV fueron monitoreados a lo largo del tiempo.
Principales resultados:
- No se detectó un aumento significativo en los títulos anti-HAV en la mayoría de los pacientes.
- Un paciente mostró un ligero aumento, y dos mostraron una disminución en los títulos anti-HAV.
- Estos hallazgos no apoyaron la participación del virus de la hepatitis A en el brote.
Conclusiones:
- Es poco probable que el virus de la hepatitis A haya causado este brote de hepatitis aguda.
- Se excluye el virus de la hepatitis A como causa de la enfermedad hepática crónica observada después del brote.
- El brote fue probablemente hepatitis no A no B, no reportada previamente en una unidad de hemodiálisis del Reino Unido, y asociada con disfunción hepática persistente.
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