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Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
Published on: September 25, 2011
Deleted in Cáncer Colorectal (DCC) codifica un receptor de la netrina
K Keino-Masu1, M Masu, L Hinck
1Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143-0452, USA.
Cell
|October 18, 1996
Resumen
Deleted in Colorectal Cancer (DCC) actúa como un receptor para la netrina-1, guiando el desarrollo de axones comisurales en la médula espinal. Este hallazgo revela un mecanismo clave en el desarrollo neuronal y la orientación de los axones.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Molecular Biología Molecular
- Biología del desarrollo Biología del desarrollo.
Sus antecedentes:
- La orientación axonal es crucial para el desarrollo del sistema nervioso.
- Los quimioatractores difusibles median en la búsqueda del camino del axón.
- Las netrinas son conocidos como quimioatractores para los axones comisurales.
Objetivo del estudio:
- Para dilucidar el mecanismo de la quimioatracción de la netrina-1.
- Para identificar el receptor de la netrina-1 en los axones comisurales.
Principales métodos:
- Análisis inmunohistoquímico de la expresión de DCC en los axones comisurales espinales.
- Ensayos in vitro para probar la actividad de unión a la netrina-1 del DCC.
- Bloqueo de experimentos utilizando un anticuerpo contra el DCC para inhibir el crecimiento del axón.
Principales resultados:
- Deleted in Cáncer Colorectal (DCC) se expresa en los axones comisurales espinales.
- El DCC se une a la netrina-1.
- El bloqueo mediado por anticuerpos de DCC inhibe el crecimiento del axón dependiente de netrina-1.
Conclusiones:
- El DCC funciona como un receptor para la netrina-1.
- El DCC media en la orientación de los axones comisurales por parte de la netrina-1.
- Esta interacción es crítica para el desarrollo de la médula espinal de los vertebrados.
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