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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 15, 2010
El virus del herpes humano KSHV codifica un receptor acoplado a la proteína G constitutivamente activo vinculado a la
L Arvanitakis1, E Geras-Raaka, A Varma
1Department of Pathology, Cornell University Medical College, New York 10021, USA.
Nature
|January 23, 1997
Resumen
El herpesvirus asociado al sarcoma de Kaposi (KSHV) codifica un receptor acoplado a la proteína G que envía señales de forma independiente y promueve el crecimiento celular. Este descubrimiento identifica un potencial oncogén viral que contribuye a las malignidades asociadas al KSHV.
Área de la Ciencia:
- Virología Virología.
- Oncología Oncología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- El herpesvirus asociado al sarcoma de Kaposi (KSHV), o el herpesvirus humano 8 (HHV 8), está relacionado con el sarcoma y los linfomas de Kaposi, particularmente en pacientes con SIDA.
- KSHV pertenece a la familia de los herpesvirus gamma, compartiendo similitudes con los virus linfotrópicos como el herpesvirus Saimiri y el virus Epstein-Barr.
Objetivo del estudio:
- Para investigar la función de un recientemente identificado receptor acoplado a la proteína G (GPCR) codificado por KSHV.
- Para determinar si el KSHV GPCR actúa como un receptor de señalización y contribuye a la oncogénesis viral.
Principales métodos:
- Clonado de un fragmento del genoma de KSHV para identificar el marco de lectura abierto para el supuesto GPCR.
- Análisis de la actividad de señalización del KSHV GPCR en la vía de la fosfoinositida-inositoltrisfosfato-proteína quinasa C.
- Evaluación del efecto del KSHV GPCR en la proliferación celular.
Principales resultados:
- El GPCR codificado por KSHV fue confirmado como un receptor de señalización funcional.
- Este receptor viral exhibe actividad constitutiva (independiente del agonista).
- Se demostró que el KSHV GPCR estimula la proliferación celular.
Conclusiones:
- El KSHV GPCR es un receptor de señalización de buena fe con actividad constitutiva.
- La capacidad del receptor para estimular la proliferación celular sugiere su papel como oncogén viral.
- Este hallazgo proporciona información sobre los mecanismos de las malignidades inducidas por KSHV.
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