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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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Una metaloproteinasa desintegrina que libera el factor de necrosis tumoral alfa de las células

R A Black1, C T Rauch, C J Kozlosky

  • 1Immunex Corporation, Seattle, Washington 98101, USA. rblack@immunex.com

Nature
|February 20, 1997
PubMed
Resumen

Los investigadores identificaron una nueva enzima, la enzima de conversión de TNF-alfa (TACE), responsable de eliminar el factor de necrosis tumoral alfa. La inhibición de TACE reduce la producción de TNF-alfa soluble, allanando el camino para nuevas estrategias terapéuticas.

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