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La progresión a la demencia en pacientes con pérdida de memoria aislada
Lancet (London, England)
|March 15, 1997
Resumen
Los pacientes con pérdida de memoria aislada tienen un mayor riesgo de desarrollar demencia. Se recomienda una estrecha vigilancia para las personas que experimentan pérdida de memoria severa sin otros déficits cognitivos.
Área de la Ciencia:
- Neurología Neurología.
- Gerontología Gerontología.
- Ciencias Cognitivas Ciencias Cognitivas.
Sus antecedentes:
- El diagnóstico de demencia requiere pérdida de memoria más otro deterioro cognitivo.
- La progresión de la pérdida de memoria aislada a la demencia no se entiende bien.
- Este estudio investiga el desarrollo de la demencia en pacientes con pérdida de memoria aislada severa.
Objetivo del estudio:
- Para determinar el riesgo de demencia en pacientes con pérdida de memoria aislada severa.
- Para entender la historia natural de la pérdida de memoria aislada.
- Para identificar los predictores de la progresión de la demencia.
Principales métodos:
- Se siguió a 21 pacientes con pérdida de memoria aislada severa durante una media de 48 meses.
- Los comparó con 198 pacientes con otras quejas cognitivas.
- Pruebas neuropsicológicas administradas al inicio.
Principales resultados:
- El 48% de los pacientes con pérdida de memoria aislada desarrollaron demencia frente al 18% en el grupo de comparación.
- El tiempo promedio hasta el diagnóstico de demencia fue de 3,77 años para los pacientes aislados con pérdida de memoria.
- Las pruebas neuropsicológicas no predijeron la progresión de la demencia.
Conclusiones:
- La pérdida de memoria aislada severa indica un mayor riesgo de demencia.
- Los pacientes con pérdida de memoria aislada requieren un seguimiento médico cercano.
- Investigaciones adicionales pueden explorar los marcadores de diagnóstico temprano.
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