Nevios displásicos clínicamente reconocidos. Un factor de riesgo central para el melanoma cutáneo
Video Experimental Relacionado
Updated: Nov 2, 2026
06:09
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
M A Tucker1, A Halpern, E A Holly
1Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md, 20892-7372, USA. tuckerp@epndce.nci.nih.gov
JAMA
|May 14, 1997
Resumen
El número y el tipo de lunares tienen un impacto significativo en el riesgo de melanoma. Los nevi clínicamente displásicos, en particular, confieren un riesgo sustancial, lo que permite la identificación de individuos de alto riesgo para la intervención temprana.
Área de la Ciencia:
- Dermatología Dermatología dermatología.
- Oncología Oncología.
- Epidemiología La epidemiología.
Sus antecedentes:
- El melanoma es una preocupación significativa para la salud pública.
- Nevi (moles) son lesiones cutáneas comunes, y su relación con el desarrollo del melanoma requiere una mayor aclaración.
Objetivo del estudio:
- Investigar la asociación entre la cantidad y las características de los nevi y la incidencia del melanoma.
- Para identificar tipos y recuentos específicos de nevus que indican un riesgo elevado de melanoma.
Principales métodos:
- Se realizó un estudio de caso-control en el que participaron 716 pacientes con melanoma y 1014 controles.
- La recopilación de datos incluyó entrevistas, exámenes completos de la piel y fotografía / biopsia de nevi atípicos.
Principales resultados:
- El riesgo de melanoma se correlaciona fuertemente con el número de pequeños nevos, grandes nevos no displásicos y clínicamente nevos displásicos.
- Un nevus clínicamente displásico duplicaba el riesgo de melanoma, mientras que diez o más aumentaban el riesgo doce veces.
- Los nevos congénitos no mostraron una asociación con un mayor riesgo de melanoma.
Conclusiones:
- Los nevi clínicamente displásicos representan un factor de riesgo sustancial para el desarrollo de melanoma.
- Los nevi no displásicos conllevan un riesgo menor, pero su cantidad sigue siendo relevante.
- Las características de Nevus pueden ayudar a los médicos a identificar a las personas con alto riesgo de melanoma, facilitando las estrategias de detección y prevención específicas.
Videos de Conceptos Relacionados
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:14Changes in Skin Color: Clinical Perspectives
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:11Papillary Dermis
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...