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Liberación anormal de epinefrina en adultos jóvenes con altas presiones sanguíneas personales y parentales altas
S B Harrap1, R Fraser, G C Inglis
1Medical Research Council Blood Pressure Unit, Western Infirmary, Glasgow, UK. s.harrap@physiology.unimelb.edu.au
Circulation
|July 15, 1997
Resumen
La presión arterial alta (PA) en adultos jóvenes está relacionada con el aumento del peso corporal y los niveles de insulina, lo que refleja factores del estilo de vida. Una respuesta única a la epinefrina indica una combinación de influencias genéticas y ambientales en aquellos con presión arterial alta y antecedentes familiares.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- El síndrome metabólico.
- Investigación de la Hipertensión Investigación de la Hipertensión
Sus antecedentes:
- La actividad del sistema nervioso simpático está implicada en la hipertensión.
- La dieta y el peso corporal son posibles contribuyentes a la presión arterial alta.
- Este estudio investigó la predisposición a la presión arterial alta en adultos jóvenes de familias con historias definidas de presión arterial alta.
Objetivo del estudio:
- Para determinar el papel de la dieta y el peso corporal en la predisposición a la presión arterial alta.
- Examinar la relación entre la actividad del sistema nervioso simpático y la presión arterial.
- Investigar los factores genéticos y ambientales que influyen en la hipertensión.
Principales métodos:
- Estudió a 100 adultos jóvenes con presión arterial alta o baja y presión arterial familiar conocida.
- Los niveles plasmáticos medidos de catecolaminas, glucosa e insulina antes y después de la carga de glucosa oral.
- Analizó las correlaciones entre los marcadores fisiológicos y la presión arterial, teniendo en cuenta la historia familiar.
Principales resultados:
- La norepinefrina plasmática en ayunas se correlacionó significativamente con la presión arterial media.
- Las personas con presión arterial alta eran más pesadas, más gordas y mostraban un mayor aumento de insulina después de la glucosa.
- Los hijos con hipertensión arterial y antecedentes parentales de hipertensión arterial exhibieron un aumento anormal de epinefrina después de la glucosa.
Conclusiones:
- La presión arterial alta se asocia con un aumento del peso corporal y la hiperinsulinemia, lo que refleja el entorno y el comportamiento personal.
- La liberación anormal de epinefrina en individuos con presión arterial alta con antecedentes familiares sugiere una combinación de factores genéticos, ambientales y de comportamiento.
- El entorno personal y el comportamiento influyen significativamente en la hipertensión, independientemente de los antecedentes familiares.
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