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Inestabilidad del flujo sanguíneo cerebral en diabéticos insulino-dependientes
Lancet (London, England)
|December 8, 1979
Resumen
El flujo sanguíneo cerebral (FCB) puede ser inestable en los diabéticos insulinodependientes, con caídas significativas observadas. Estas fluctuaciones de la FBC pueden causar sensaciones de desmayo y contribuir al riesgo de accidente cerebrovascular en pacientes diabéticos.
Área de la Ciencia:
- Neurología Neurología.
- Endocrinología Endocrinología.
- Ciencias Cardiovasculares Ciencias Cardiovasculares
Sus antecedentes:
- La diabetes mellitus dependiente de insulina (IDDM) está asociada con complicaciones microvasculares.
- La regulación del flujo sanguíneo cerebral (FCB) puede verse afectada en individuos diabéticos.
- Comprender las variaciones de CBF es crucial para el manejo de pacientes diabéticos.
Objetivo del estudio:
- Para investigar la estabilidad del flujo sanguíneo cerebral (FCB) en diabéticos insulinodependientes.
- Para determinar si los cambios en la CBF se correlacionan con síntomas como el desmayo.
- Explorar las implicaciones de la inestabilidad de la CBF en la patogénesis de la enfermedad cerebrovascular diabética.
Principales métodos:
- El flujo sanguíneo cerebral (FCB) se midió en 23 pacientes diabéticos insulinodependientes.
- Las mediciones se tomaron antes y 2-3 horas después de la administración de insulina y el desayuno.
- Se analizaron los cambios en la CBF y se registraron los síntomas informados por los pacientes.
Principales resultados:
- CBF mostró una variación significativa durante el día en 10 de 23 pacientes diabéticos.
- Se observó una caída significativa en la CBF en 9 pacientes.
- Tres pacientes que experimentaron las mayores caídas de CBF informaron sensaciones de desmayo inminente, incluso sin hipoglucemia.
Conclusiones:
- El flujo sanguíneo cerebral (FCB) es notablemente inestable en los diabéticos insulinodependientes en comparación con los controles.
- Las reducciones repentinas del FBC pueden precipitar sensaciones de desmayo en los diabéticos, independientemente de la hipoglucemia.
- Estas fluctuaciones de CBF son relevantes para comprender el riesgo de accidente cerebrovascular y la patogénesis en la diabetes insulino-dependiente.
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