Hambre en humanos inducida por 2-deoxy-D-glucose: control glucoprivo de las preferencias gustativas y la ingesta de alimentos
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Science (New York, N.Y.)
|December 9, 1977
Resumen
La administración de 2-deoxy-D-glucose (2DG) a los seres humanos causa glucopenia intracelular, aumentando el hambre y las calificaciones de agrado para las soluciones dulces. Este hambre inducida experimentalmente puede ser aliviada por la ingesta de alimentos, ofreciendo un método para estudiar los comportamientos apetitosos.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Fisiología Humana Fisiología Humana.
- Ciencias del comportamiento Ciencias del comportamiento.
Sus antecedentes:
- La glucopenia intracelular es un estado de baja glucosa dentro de las células.
- La 2-deoxy-D-glucose (2DG) es un análogo de la glucosa que inhibe el metabolismo de la glucosa.
- La glucopenia puede desencadenar respuestas fisiológicas y conductuales relacionadas con el hambre y el equilibrio energético.
Objetivo del estudio:
- Investigar los efectos de la glucopenia intracelular inducida experimentalmente sobre el hambre humana y las respuestas afectivas.
- Examinar el papel de 2DG en la modulación de la ingesta de alimentos y comportamientos relacionados.
- Explorar 2DG como una herramienta para estudiar el comportamiento apetitivo y la regulación neuroendocrina.
Principales métodos:
- La administración de 2-deoxy-D-glucose (2DG) a los participantes humanos.
- Medición de las calificaciones de hambre y estimaciones de agrado para soluciones de sacarosa.
- Evaluación de la ingesta de alimentos después de la administración de 2DG.
- Observación de los mecanismos de contrarregulación para elevar la glucosa en el plasma.
Principales resultados:
- La glucopenia intracelular inducida por 2DG aumentó significativamente las calificaciones de hambre.
- Las calificaciones de agrado para las soluciones de sacarosa se elevaron bajo condiciones glucopénicas.
- Se observó un aumento en la ingesta de alimentos, lo que alivió el hambre inducida experimentalmente.
- Se observó la activación de mecanismos de contrarregulación para aumentar las concentraciones plasmáticas de glucosa.
Conclusiones:
- La glucopenia intracelular inducida experimentalmente a través de 2DG estimula eficazmente el hambre y altera las respuestas afectivas a las señales de alimentos en los seres humanos.
- La ingesta de alimentos sirve para aliviar el hambre inducida por 2DG, destacando la regulación homeostática del apetito.
- La administración de 2DG ofrece un modelo valioso para estudiar el comportamiento apetitivo humano y el control neurohumoral de las funciones hipotalámicas.
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