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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
Published on: May 22, 2013
Telómeros, cáncer y envejecimiento. Alterando la duración de la vida humana
1Richard & Rhoda Goldman School of Public Policy & Center for the Economics and Demography of Aging, University of California, Berkeley, USA.
JAMA
|October 29, 1997
Resumen
Los avances en la investigación del envejecimiento sugieren que la duración máxima de la vida humana puede no ser fija. Esto desafía las proyecciones de población actuales y requiere una reevaluación de los futuros costos de atención médica.
Área de la Ciencia:
- Gerontología Gerontología.
- Biología celular Biología celular.
- Genética La genética.
Sus antecedentes:
- Las proyecciones de población se basan en suposiciones sobre la duración de la vida humana.
- Históricamente, la duración máxima de la vida humana se ha considerado fija.
- Investigaciones recientes desafían esta suposición.
Objetivo del estudio:
- Explorar las implicaciones de la posible extensión de la esperanza de vida humana.
- Evaluar el impacto de la investigación sobre el envejecimiento en las proyecciones futuras de costos de atención médica.
- Para resaltar la incertidumbre introducida por los avances en la ciencia de la longevidad.
Principales métodos:
- Revisión de los avances recientes en biología celular y genética relacionados con el envejecimiento.
- Análisis de estudios en modelos animales sobre la manipulación de la duración de la vida (telómeros, genes, dieta).
- Evaluación del impacto potencial de estos hallazgos en el envejecimiento humano y las enfermedades.
Principales resultados:
- La senescencia celular puede ser alterada in vitro (telómeros).
- La manipulación in vivo de los genes y la dieta extiende la esperanza de vida máxima en modelos animales.
- La extensión de estos hallazgos a los seres humanos sugiere el potencial para aumentar la esperanza de vida y retrasar las enfermedades relacionadas con el envejecimiento.
Conclusiones:
- La suposición de una duración máxima fija de la vida humana es cada vez más cuestionada.
- Extender la esperanza de vida humana podría alterar significativamente las proyecciones de costos de atención médica en el futuro.
- La incertidumbre en las proyecciones de la esperanza de vida complica la planificación financiera precisa a largo plazo para el cuidado de la salud.
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