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Updated: Sep 3, 2026
07:27
Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
Pérdidas del gusto y el olfato en el envejecimiento normal y en enfermedades
1Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. sss@acpub.duke.edu
JAMA
|October 29, 1997
Resumen
La disminución de los quimiosensores, incluidos el gusto y el olfato, es común en los adultos mayores. Esto puede afectar la nutrición, la seguridad y la calidad de vida, pero la mejora del sabor puede ayudar.
Área de la Ciencia:
- Gerontología Gerontología.
- La neurociencia es la neurociencia.
- La ciencia sensorial es la ciencia sensorial.
Sus antecedentes:
- Los cambios relacionados con la edad tienen un impacto significativo en los sentidos del gusto y el olfato.
- Estas alteraciones sensoriales pueden afectar el bienestar y los resultados de salud de un adulto mayor.
Objetivo del estudio:
- Revisar exhaustivamente la literatura científica sobre las alteraciones del gusto y el olfato en los ancianos.
- Explorar las causas, el diagnóstico, el pronóstico y el tratamiento de estos déficits quimiosensoriales.
Principales métodos:
- Una extensa búsqueda en la literatura de MEDLINE (1966-1997) utilizando los términos relevantes de MeSH.
- La inclusión de informes originales y artículos de revisión frecuentemente citados.
- Revisión sistemática, tabulación y resumen de los datos extraídos en función de la calidad y la relevancia clínica.
Principales resultados:
- Las causas comunes incluyen el envejecimiento normal, enfermedades (por ejemplo, la enfermedad de Alzheimer), medicamentos, cirugía y factores ambientales.
- Los déficits de gusto y olfato disminuyen el disfrute de los alimentos, lo que plantea riesgos de deficiencias nutricionales e inmunológicas.
- Estas disminuciones pueden conducir a una intoxicación alimentaria accidental o a una exposición química peligrosa.
Conclusiones:
- Las deficiencias quimiosensoriales son frecuentes en los ancianos, afectando la vida cotidiana y la salud.
- Intervenciones como el uso de alimentos con sabor mejorado pueden mejorar la ingesta de alimentos, el disfrute y el estado inmunológico.
- Abordar la pérdida del gusto y el olfato es crucial para mantener la salud y la calidad de vida de los adultos mayores.
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