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Updated: Aug 19, 2026

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation
09:40

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation

Published on: June 27, 2017

La MAP quinasa une el factor de transcripción Microphthalmia con la señalización c-Kit en los melanocitos

T J Hemesath1, E R Price, C Takemoto

  • 1Division of Pediatric Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|January 24, 1998
PubMed
Resumen

Las mutaciones de la línea germinal en la señalización Microphthalmia (Mi) y c-Kit impactan el desarrollo de mastocitos y melanocitos. Descubrimos que la señalización c-Kit activa la MAP quinasa, que fosforila el Mi, lo que regula la expresión génica de la pigmentación.

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