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Estructura del dímero de oxido nítrico sintasa oxigenasa con pterina y sustrato

B R Crane1, A S Arvai, D K Ghosh

  • 1Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|April 16, 1998
PubMed
Resumen

Los conocimientos estructurales sobre la síntesis de óxido nítrico inducible por citoquinas revelan cómo las interacciones de unión al sustrato y los cofactores permiten la síntesis de óxido nítrico. La dimerización y la unión de pterina crean un canal de centro activo profundo crucial para la función y regulación de la enzima.

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