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Isolation of Viable Adipocytes and Stromal Vascular Fraction from Human Visceral Adipose Tissue Suitable for RNA Analysis and Macrophage Phenotyping
Published on: October 27, 2020
La acumulación de grasa abdominal visceral asociada con el uso de indinavir
K D Miller1, E Jones, J A Yanovski
1Department of Critical Care Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. kmiller@atlas.niaid.nih.gov
Lancet (London, England)
|April 3, 1998
Resumen
Los pacientes con VIH que reciben indinavir pueden desarrollar un aumento de grasa intraabdominal, lo que lleva a síntomas abdominales. Esta acumulación de tejido adiposo visceral (VAT) está relacionada con el uso de indinavir y el aumento de los triglicéridos.
Área de la Ciencia:
- Investigación sobre el VIH/SIDA en la investigación del VIH/SIDA.
- Farmacología Farmacología.
- Imágenes médicas de imagen.
Sus antecedentes:
- Algunos pacientes con VIH-1 en terapia de combinación con indinavir informan un aumento de la circunferencia abdominal y la plenitud.
- El estudio investiga si estos síntomas están relacionados con cambios en la distribución de la grasa abdominal y el uso de indinavir.
Objetivo del estudio:
- Para determinar si el uso de indinavir está asociado con un aumento de la acumulación de grasa intraabdominal en pacientes con VIH-1.
- Para explorar la relación entre los síntomas abdominales, el tejido adiposo visceral (VAT) y el tratamiento con indinavir.
Principales métodos:
- Las tomografías computarizadas abdominales midieron el tejido adiposo total (TAT) y el VAT a nivel vertebral L4.
- Se compararon los ratios VAT:TAT en usuarios sintomáticos de indinavir, usuarios asintomáticos de indinavir y no usuarios.
Principales resultados:
- Los usuarios sintomáticos de indinavir tenían ratios de IVA: TAT significativamente más altos (0,70) en comparación con los usuarios asintomáticos (0,59) y los no usuarios (0,40).
- La relación VAT:TAT se correlacionó con la duración del tratamiento con indinavir (r=0,47, p=0,01).
- El aumento de los niveles séricos de triglicéridos se correlacionó con mayores proporciones de IVA: TAT.
Conclusiones:
- El tratamiento con indinavir puede conducir a la acumulación de grasa intraabdominal, causando síntomas en algunos pacientes con VIH-1.
- Se justifica una mayor investigación sobre los efectos de los inhibidores de la proteasa en la distribución de la grasa corporal y los mecanismos subyacentes.
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