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Bloqueadores de los canales de calcio y el riesgo de cáncer
L Rosenberg1, R S Rao, J R Palmer
1Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline, Mass 02146, USA.
JAMA
|April 9, 1998
Resumen
El uso de bloqueadores de los canales de calcio no aumenta el riesgo general de cáncer. Este estudio no encontró ningún vínculo con la mayoría de los cánceres, excepto por una posible asociación con el riesgo de cáncer de riñón.
Área de la Ciencia:
- Farmacología cardiovascular farmacología cardiovascular
- Oncología Oncología.
- Epidemiología La epidemiología.
Sus antecedentes:
- La evidencia emergente sugiere que los bloqueadores de los canales de calcio (CCB) pueden elevar el riesgo de cáncer.
- Existen preocupaciones con respecto a la asociación de CCB con tipos generales y específicos de cáncer.
Objetivo del estudio:
- Para investigar la asociación entre el uso de bloqueadores de los canales de calcio y el riesgo de cáncer.
- Para determinar si los CCB aumentan el riesgo de cáncer general o de tipos específicos de cáncer.
Principales métodos:
- Se realizó un estudio de casos y controles de vigilancia de drogas utilizando datos de 1983 a 1996.
- Se analizaron 9513 pacientes con cáncer y 6492 controles, de 40 a 69 años de edad.
- El estudio examinó la incidencia general de cáncer y 23 tipos específicos de cáncer.
Principales resultados:
- El uso de bloqueadores de los canales de calcio no mostró una asociación significativa con el riesgo general de cáncer (RR, 1.1; IC del 95%, 0.9-1.3).
- No se encontró un aumento significativo del riesgo para la mayoría de los cánceres individuales, excepto el cáncer de riñón (RR, 1.8; IC del 95%, 1.1-2.7).
- Otros antihipertensivos, los betabloqueantes y los inhibidores de la ECA, también se relacionaron con el cáncer de riñón.
Conclusiones:
- El uso de bloqueadores de los canales de calcio no parece estar relacionado con el riesgo general de cáncer.
- A excepción del cáncer de riñón, las CCB no se asocian significativamente con un mayor riesgo de otros cánceres específicos.
- La asociación con el cáncer de riñón puede estar relacionada con la hipertensión o sus tratamientos.
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