La supresión de la subunidad alfa4 del receptor GABA (((A) evita las propiedades de abstinencia de un esteroide

S S Smith1, Q H Gong, F C Hsu

  • 1Department of Neurobiology and Anatomy, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19129, USA. smiths@auhs.edu

Nature
|May 15, 1998
PubMed
Resumen

La abstinencia de progesterona en ratas imita los síntomas del síndrome premenstrual (SPM) al reducir los niveles cerebrales de 3alfa,5alfa-THP, un potenciador de GABA. Esto conduce a una mayor susceptibilidad a las convulsiones y a una expresión alterada del receptor GABA (A).

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