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La asociación de las cepas virulentas de Helicobacter pylori con la enfermedad isquémica del corazón
V Pasceri1, G Cammarota, G Patti
1Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Circulation
|May 20, 1998
Resumen
La infección crónica por Helicobacter pylori está relacionada con la enfermedad isquémica del corazón. Las cepas CagA-positivas más virulentas, no solo las bacterias, se asocian con un mayor riesgo, lo que sugiere un papel en la aterogénesis.
Área de la Ciencia:
- Cardiología Cardiología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Gastroenterología y Gastroenterología.
Sus antecedentes:
- Estudios previos sugieren un vínculo entre la infección por Helicobacter pylori y la enfermedad isquémica del corazón (IHD).
- El papel de la virulencia bacteriana frente a los factores de confusión (edad, clase social) en esta asociación sigue sin estar claro.
Objetivo del estudio:
- Investigar la asociación entre la infección por Helicobacter pylori, específicamente las cepas virulentas CagA positivas, y la enfermedad isquémica del corazón.
- Para determinar si la asociación observada se debe a la virulencia bacteriana o factores de confusión.
Principales métodos:
- Estudio de caso-control en el que participaron 88 pacientes con EII y 88 controles emparejados.
- Prevalencia estimada de la infección por Helicobacter pylori y las cepas CagA positivas.
- Ajustado por edad, sexo, factores de riesgo cardiovascular y clase social.
Principales resultados:
- La infección por Helicobacter pylori fue significativamente más prevalente en los pacientes con EII (62%) que en los controles (40%), OR=2.8.
- La prevalencia de cepas CagA-positivas fue significativamente mayor en pacientes con EIH (43%) frente a los controles (17%), OR=3.8.
- La prevalencia de cepas CagA-negativas no difería entre los pacientes con EII (19%) y los controles (23%), OR=0,8.8.
Conclusiones:
- La asociación entre Helicobacter pylori y IHD está vinculada a cepas bacterianas más virulentas.
- Estos hallazgos apoyan la hipótesis de que Helicobacter pylori puede contribuir a la aterogénesis a través de la inflamación crónica.
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