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Updated: Jun 20, 2026

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Estructura cristalina de un dimero STAT-1 fosforilado por tirosina unido al ADN

X Chen1, U Vinkemeier, Y Zhao

  • 1The Rockefeller University, New York, New York 10021, USA.

Cell
|June 18, 1998
PubMed
Resumen

La estructura cristalina homodímero del transductor de señales y activador de la transcripción 1 (STAT-1) revela una abrazadera en forma de C alrededor del ADN. Las interacciones específicas del dominio SH2 estabilizan la unión al ADN, lo que sugiere un papel en la regulación génica.

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