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Control local del flujo de información en colaterales segmentales y ascendentes de aferentes únicos
J Lomelí1, J Quevedo, P Linares
1Department of Physiology, Biophysics and Neurosciences, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México DF, México.
Nature
|October 23, 1998
Resumen
Las interneuronas GABA de la médula espinal controlan selectivamente la información sensorial. La inhibición presináptica permite la modulación independiente de diferentes ramas de fibra aferente, lo que permite la comunicación neuronal dirigida.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Fisiología de la médula espinal fisiología de la médula espinal
- Procesamiento Sensorial Procesamiento Sensorial
Sus antecedentes:
- Las interneuronas GABA de la médula espinal de los vertebrados median la inhibición presináptica de los aferentes sensoriales.
- La selectividad de este control presináptico sobre las ramas intraspinarias distintas de los aferentes individuales sigue sin estar clara.
Objetivo del estudio:
- Investigar la naturaleza local del control presináptico en los aferentes individuales del huso muscular.
- Para determinar si las colaterales segmentales y ascendentes de los aferentes pueden ser moduladas de forma independiente.
Principales métodos:
- Medida simultánea de la despolarización del aferente primario en dos colaterales intraspinales del mismo aferente del huso muscular.
- Se registra a partir de las garantías que terminan en L6-L7 y ascienden a L3 (columna de Clarke).
Principales resultados:
- Existen mecanismos centrales que controlan independientemente la eficacia sináptica de las garantías segmentales y ascendentes.
- La inhibición presináptica focal permite la fraccionamiento de las ramas aferentes intraspinarias.
Conclusiones:
- La inhibición presináptica selectiva permite un control dinámico y fraccionado del flujo de información sensorial.
- Este mecanismo puede desacoplar las dianas postsinápticas espinales que reciben información de una fuente sensorial común.
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