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Updated: Jul 23, 2026
22:27
Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
Nuevas metas para el Proyecto del Genoma Humano de EE.UU.: 1998-2003
F S Collins1, A Patrinos, E Jordan
1National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. fc23a@nih.gov
Science (New York, N.Y.)
|October 23, 1998
Resumen
El Proyecto Genoma Humano está acelerando su línea de tiempo, con el objetivo de una secuencia completa de ADN humano en 2003. Este ambicioso plan incluye un borrador de trabajo para el año 2001 y avances en la tecnología de secuenciación y la investigación genómica.
Área de la Ciencia:
- La genómica es la genómica.
- Biología Molecular Biología Molecular
- La bioinformática es la bioinformática.
Sus antecedentes:
- El Proyecto del Genoma Humano (PGH) cumplió con éxito sus objetivos de 1993-1998.
- Se ha establecido un plan estratégico revisado (1998-2003) para guiar los futuros esfuerzos de HGP.
Objetivo del estudio:
- Para esbozar los objetivos actualizados del HGP, haciendo hincapié en la finalización de la secuencia de ADN humano.
- Para detallar los avances en tecnología de secuenciación, genómica funcional y genómica comparativa.
Principales métodos:
- Secuenciación acelerada del ADN humano para producir un borrador de trabajo en 2001 y la secuencia completa en 2003.
- Desarrollo de tecnologías avanzadas de secuenciación y herramientas de genómica funcional.
- Estudios comparativos de genómica que incluyen *Caenorhabditis elegans*, *Drosophila melanogaster* y el genoma del ratón.
Principales resultados:
- Cumplimiento de todos los objetivos principales del plan HGP 1993-1998.
- Establecimiento de un calendario acelerado para la secuenciación del genoma humano.
- Iniciación de estudios exhaustivos sobre la variación de la secuencia del genoma humano y la genómica funcional.
Conclusiones:
- El Proyecto del Genoma Humano está en camino de completar antes la secuencia del ADN humano.
- El proyecto producirá avances significativos en la tecnología de secuenciación, la genómica funcional y la comprensión de la variación del genoma.
- Los impactos más amplios incluyen estudios de implicaciones éticas, legales y sociales, desarrollo de la bioinformática y capacitación de científicos.
Palabras clave:
Investigaciones biomédicas y conductuales.Departamento de Energía del Departamento de Energía.Genética y reproducción.Proyecto del genoma humano Proyecto del genoma humanoNIH-DOE Grupo de Trabajo sobre las implicaciones éticas, legales y sociales (ELSI)Institutos Nacionales de la Salud de los Estados Unidos.
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