Video Experimental Relacionado
Updated: Aug 1, 2026
08:38
Transretinal ERG Recordings from Mouse Retina: Rod and Cone Photoresponses
Published on: March 14, 2012
Los receptores de kainato median la transmisión sináptica entre los conos y las células bipolares "apagadas" en una
1Department of Ophthalmology and Visual Science, University of Texas Houston Health Science Center, 77030, USA. sdevries@eye.med.uth.tmc.edu
Nature
|January 29, 1999
Resumen
Los fotorreceptores de cono utilizan receptores de kainato para transmitir señales visuales a las células bipolares. La desensibilización del receptor evita la saturación de la señal, lo que permite una visión precisa a través de los niveles de luz.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Visión Visión Ciencia Ciencia.
- La fototransducción es la fototransducción.
Sus antecedentes:
- Los fotorreceptores de la retina transmiten información visual a través del glutamato.
- Fuera de las células bipolares utilizan receptores ionotrópicos de glutamato.
- Los mecanismos que optimizan la transmisión de la señal en las células bipolares no están claros.
Objetivo del estudio:
- Investigar los receptores de glutamato que median la transmisión de células bipolares cone-off.
- Determinar cómo estos receptores están optimizados para la transmisión de señales pequeñas.
Principales métodos:
- Registros electrofisiológicos de células cónicas y bipolares en rebanadas de retina.
- Análisis de las corrientes sinápticas y la cinética de los receptores.
Principales resultados:
- La transmisión de células bipolares cone-off está mediada por receptores de glutamato que prefieren el kainato.
- Los conos adaptados a la oscuridad desensibilizan los receptores postsinápticos de kainato, reduciendo la corriente.
- La recuperación lenta de la desensibilización del receptor evita la saturación durante las respuestas a la luz.
Conclusiones:
- La desensibilización del receptor de kainato en las células bipolares optimizan la transmisión de la señal.
- Este mecanismo permite que las células bipolares funcionen a través del rango dinámico del cono.
- Asegura un procesamiento visual preciso bajo condiciones de luz variables.
Videos de Conceptos Relacionados
01:32The Retina
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
01:24Vision
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
01:11Channel Rhodopsins
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
01:21G-Protein Gated Ion Channels
GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
Sensory organs,...
01:20Anatomy of the Eyeball
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...