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Coupled Assays for Monitoring Protein Refolding in Saccharomyces cerevisiae
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Published on: July 9, 2013

La traducción y el plegamiento de las proteínas están acoplados por una quinasa residente en el retículo

H P Harding1, Y Zhang, D Ron

  • 1Skirball Institute of Biomolecular Medicine, Department of Medicine, NYU School of Medicine, New York 10016, USA.

Nature
|February 4, 1999
PubMed
Resumen

El estrés en el retículo endoplasmático (ER) desencadena una vía que reduce la síntesis de proteínas. Un gen recientemente identificado, PERK, codifica una proteína quinasa que fosforila el factor de iniciación eucariota-2alfa (eIF2alfa), atenuando la traducción durante el estrés ER.

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