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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Un microchip de liberación controlada
J T Santini1, M J Cima, R Langer
1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. rlanger@mid.edu
Nature
|February 13, 1999
Resumen
Los investigadores desarrollaron un nuevo microchip de silicio para la administración de fármacos pulsables y bajo demanda. Este dispositivo de estado sólido utiliza la disolución electroquímica para la liberación controlada de varias sustancias químicas.
Área de la Ciencia:
- Ingeniería Biomédica Ingeniería Biomédica.
- Ciencia de los materiales Ciencia de los materiales.
- Sistemas de suministro de drogas Sistemas de suministro de drogas.
Sus antecedentes:
- La administración tradicional de medicamentos a menudo se basa en materiales poliméricos que responden a estímulos externos.
- La microfabricación ofrece una alternativa para crear dispositivos activos con un control fluídico preciso.
Objetivo del estudio:
- Introducir un nuevo microchip de silicio en estado sólido para la liberación controlada y bajo demanda de sustancias químicas.
- Para demostrar un nuevo mecanismo para lograr la liberación pulsátil de fármacos.
Principales métodos:
- Desarrollo de un microchip con micro depósitos que contienen sustancias químicas.
- Utilizando la disolución electroquímica de membranas delgadas de ánodo como el mecanismo de liberación.
- Estudios de prueba de principio utilizando oro y solución salina como materiales modelo.
Principales resultados:
- Se ha demostrado la liberación controlada y pulsante de sustancias químicas desde el microchip.
- Implementó con éxito la disolución electroquímica para desencadenar la liberación de sustancias.
- Valida la capacidad del microchip para suministrar productos químicos individuales o múltiples.
Conclusiones:
- El microchip de silicio desarrollado ofrece una plataforma prometedora para la administración de fármacos pulsátiles bajo demanda y controlada.
- La disolución electroquímica proporciona un mecanismo viable para el control preciso de la liberación de sustancias químicas.
- Esta tecnología tiene aplicaciones potenciales en sistemas avanzados de administración terapéutica.
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