冠動脈疾患と鉄の状態:前向きな研究のメタ解析
1Clinical Trial Service Unit, Nuffield Department of Clinical Medicine, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK. john.danesh@balliol.ox.ac.uk
Circulation
|February 23, 1999
まとめ
このメタ解析では,血清フェリチンやトランスフリーンの飽和度などの鉄のステータスマーカーと冠動脈疾患 (CHD) のリスクを関連付ける有力な証拠が見つかりませんでした. 潜在的な関連性を明らかにするためにさらなる研究が必要である.
科学分野:
- 心血管伝染病学 心血管伝染病学
- 栄養科学とは,栄養科学である.
- バイオマーカー バイオマーカー
背景:
- 鉄の状態と冠動脈性心疾患 (CHD) の関連性について,矛盾する結果があります.
- 将来の疫学研究は,さまざまな結果でこの関係を調査しています.
研究 の 目的:
- 鉄の状態マーカーとCHDリスクの間の疫学的な関連性を定量的に評価する.
- 系統的レビューとメタアナリシスを通じて,複数の見通し研究から得られた結果を統合する.
主な方法:
- 公開された前向きな研究の体系的なレビューとメタ解析.
- 鉄のステータスマーカー (血清フェリチン,トランスフリン飽和度など) を報告した研究を含む. そしてCHDの発生率です.
- 研究特性の抽象化,混同因子調整,リスク推定.
主要な成果:
- 7800件のCHD症例を含む12件の研究が分析されました.
- 血清フェリチン (RR 1.0,95%CI 0.8-1.3) の有意な関連性は見つかりませんでした.
- トランスフリン飽和度 (RR 0.9,95%CI 0.7-1.1),総鉄結合能力,血清鉄,および食事中の鉄も,無意味なリスク比を示した.
結論:
- 現在出版されている前向きな研究では,鉄の状態と冠動脈疾患との間の強い疫学的関連性に対する確固たる証拠が不足しています.
- 既存のデータは,一般的な鉄のバイオマーカーと心血管リスクの間の有意な関連性を支持していません.
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