不安定なアンギナを患っている患者の退院時にC反応性タンパク質のレベルが上昇すると,再発する不安定性が予測されます
L M Biasucci1, G Liuzzo, R L Grillo
1Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy. biasucci@pelagus.it
Circulation
|February 23, 1999
まとめ
不安定なアンギナ放出後のC反応性タンパク質 (CRP) の持続的な上昇は,再発的な不安定性のリスクが高いことを示します. このマーカーは数ヶ月間持続し,クラミジア肺炎感染症と関連しています.
科学分野:
- 心臓病学 心臓病学
- バイオマーカー バイオマーカー
- 炎症 炎症 炎症 炎症 炎症
背景:
- 不安定性胸痛は,重大な心血管疾患である.
- 放出後の炎症マーカーの評価は,リスクの階層化に不可欠です.
研究 の 目的:
- 不安定な胸痛患者の退院時にC反応性タンパク質 (CRP) 濃度が上昇しているかどうかを判断する.
- 持続的なCRP上昇と再発性心血管疾患との関連を調査する.
主な方法:
- 53人の不安定なアンギナ患者のCRP,SAA,フィブリノゲン,コレステロール,H. pyloriとC. pneumoniaeに対する抗体測定.
- 入院時に,退院時に,そして退院後3ヶ月で採取した血液サンプル.
- 不安定性または心筋梗塞の再入院を追跡するために1年間,患者を追跡しました.
主要な成果:
- 49%の患者は退院時にCRPが上昇した (>3 mg/L).
- 高解禁CRPは,再入学率の高さ (69%対15%) と著しく関連していました.
- 高いCRPレベルは,再発性不安定性のリスクの増加と相関しており,C. pneumoniaeタイターと関連していました.
結論:
- 不安定性アンギナ後のCRPの上昇は,進行中の炎症を示唆し,再発する不安定性を予測します.
- 慢性感染症 (C. pneumoniaeなど) と関連する可能性のある持続的な炎症は,サブクリニック的不安定性の特徴である可能性があります.
- C-反応性タンパク質と血清アミロイドAタンパク質は,不安定なアンギナにおける貴重な予後マーカーである.
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