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Updated: Jul 22, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
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シクロスポリンは,細胞自律的なメカニズムによってがんの進行を誘発する

M Hojo1, T Morimoto, M Maluccio

  • 1Department of Transplantation Medicine and Extracorporeal Therapy, Weill Medical College of Cornell University, New York, New York 10021, USA.

Nature
|February 24, 1999
PubMed
まとめ

免疫抑制剤であるサイクロスポリンは,宿主免疫から独立した細胞自律的メカニズムを通じて,がん細胞の侵入性を直接増加させます. このプロセスは,成長因子β (TGFβ) の変容を伴うもので,移植後の悪性腫瘍の増加に寄与する.

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