アンジオテンシン変換酵素遺伝子挿入/削除ポリモルフィズムと体力トレーニングへの反応
H Montgomery1, P Clarkson, M Barnard
1Centre for Cardiovascular Genetics, University College London, Rayne Institute, UK. h.montgomery@ucl.ac.uk
Lancet (London, England)
|February 24, 1999
まとめ
低アンジオテンシン変換酵素 (ACE) 活性を示すII型遺伝子を持つ個人は,激しい運動中により大きな筋肉と脂肪の量増加を示しました. これは,代謝効率の向上とトレーニング応答の改善を示唆しています.
科学分野:
- 運動生理学とは
- ヒューマン・ジェネティクス ヒューマン・ジェネティックス
- メタボリック研究
背景:
- 骨格筋および脂肪組織における局所レニン-アニオテンシンシステムの役割は,十分に理解されていません.
- ヒトのアンジオテンシン変換酵素 (ACE) 遺伝子 (挿入/削除) の一般的な多形態化は,ACEの活性とトレーニング応答に影響を与える.
研究 の 目的:
- ACE遺伝子の挿入/削除ポリモルフィズムと身体組成の変化との関連を調査する.
- 激しい運動中に局所的なレニン-アニオテンシンシステムの代謝効果を探求する.
主な方法:
- 3つの独立した方法 (バイオインペデンス,皮膚の厚さ,MRI) で,身体の組成の変化が評価されました.
- この研究では,若い男性兵が10週間の強烈な体力トレーニングを受けていました.
主要な成果:
- II型遺伝子のグループは,D型アレルを持つグループと比較して,脂肪質 (0.55kg) と非脂肪質 (1.31kg) で著しく高いアナボリック反応を示した.
- トレーニング中の身体形態の変化は,ACE遺伝子型に依存していた.
結論:
- 低ACE活性に関連したII遺伝子型は,厳格なトレーニング中にポジティブなエネルギーバランスと代謝効率の向上を促進する可能性があります.
- この発見は,ACE阻害剤療法で観察された利点を説明する可能性がある.
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