閉経は,更年期である

G A Greendale¹, N P Lee, E R Arriola

¹Division of Geriatrics, School of Medicine, Center for Health Sciences, University of California, Los Angeles 90095-1687, USA.

Lancet (London, England)

|February 24, 1999

まとめ

閉経は卵巣機能の停止であり,通常は51歳くらいに起こります. ホルモン置換療法は,症状の緩和と慢性疾患の予防に利点がありますが,個別化された意思決定が必要です.

科学分野:

生殖内分泌学生殖内分泌学
ゲロントロジーはゲロントロジーの学科です.
女性の健康女性の健康

背景:

閉経は,永久的な卵巣機能停止による12ヶ月のアメノレアと定義され,平均年齢は51歳です.
閉経前期は,閉経前の移行期であり,卵巣の機能の変化と熱中症のような症状の発症を伴う.
更年期移行の生理学と臨床的側面は完全に理解されていません.

研究の目的:

閉経と様々な症状や疾患との関連に関する証拠をレビューする.
症状緩和および慢性疾患予防のためのホルモン置換療法 (HRT) について議論します.
利益,リスク,患者の好みに基づいて個別化されたHRTの決定の重要性を強調する.

主な方法:

更年期に関連する症状や疾患に関する既存の証拠のレビュー.
ホルモン置換療法 (HRT) の徴候,処置,および合併症の分析.
HRTとあらゆる原因による死亡率に関する観察データの検討.

主要な成果:

観察研究では,HRTの使用は,閉経後の女性の全原因死亡率の30~50%の減少と関連していることが示唆されています.
HRTは,症状管理と慢性疾患の予防のために,異なる用量と経路で使用することができます.
HRT中に予期せぬ陰道出血が起こる場合,子宮内膜の増殖を示し,注意深くモニタリングする必要があります.

結論:

閉経後のホルモン療法は,健康にプラスとネガティブの両方の効果を持つ複雑な介入です.
女性と医療従事者との共同議論を含むHRTの個別化された意思決定は極めて重要です.
健康的な結果に関する患者の好みは,ホルモン置換療法を使用する選択を導くべきです.

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