ファミリアルパピラー甲状腺小がん:新しい臨床実体
G Lupoli1, G Vitale, M Caraglia
1Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Italia.
Lancet (London, England)
|February 25, 1999
まとめ
症例の5.9%で発見された家族性パピラ性甲状腺小がんは,攻撃的な特徴を示しています. これは,甲状腺がんの家族歴のある患者にとって,急進的な治療と密接なモニタリングが不可欠であることを示唆しています.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 腫瘍学 腫瘍学
- 遺伝学 遺伝学とは
背景:
- 非骨髄性甲状腺癌は,散発的形態と比較して,家族的な症例ではしばしば攻撃的に現れる.
- パピラ性甲状腺小がん (PTMC) は甲状腺がんのサブタイプである.
- PTMCにおける家族的なパターンの調査は,その行動を理解するために重要です.
研究 の 目的:
- papillary thyroid microcarcinoma (PTMC) が家族的に発生しているかどうかを判断する.
- 家族性PTMC.の特定の臨床的および予後的特徴を特定する.
主な方法:
- PTMCと診断された119人の患者の臨床記録の遡及的レビュー.
- 収集されたデータには,甲状腺がんの家族歴,臨床プレゼンテーション,手術の詳細,病理学,およびフォローアップの結果が含まれていました.
主要な成果:
- 甲状腺がんの家族発生は,7人の患者 (5.9%のコホート) で確認された.
- 家族的な症例では,多焦点腫瘍 (5),双方向腫瘍 (3),血管侵入 (3),リンパ節転移 (4) が観察されました.
- 3人の患者は再発を経験し,肺転移の1人の患者は11ヶ月以内に死亡しました.
結論:
- 家族性PTMCは,5.9%の症例で確認されました.
- PTMCの家族形態は,好ましくない行動を示し,積極的な治療と勤勉なフォローアップの必要性を示します.
関連する概念動画
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