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Updated: Jul 19, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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TRF2が欠けているテロメアによって誘発されるp53-およびATM依存性アポトーシス

J Karlseder1, D Broccoli, Y Dai

  • 1Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA. Cell Genesys, Foster City, CA 94405, USA.

Science (New York, N.Y.)
|February 26, 1999
PubMed
まとめ

自然染色体末端 (テロメア) は通常,アポトーシスを避けます. しかし,テロメア-リピート結合因子2 (TRF2) を阻害すると,細胞死が誘発され,テロメアがアポトーシスをシグナル化することが示唆される.

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