関連する実験動画

Updated: Jul 16, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

ネイティブのUre2pからアミロイド形成のプリオン領域のイニシアチブ in vitro

K L Taylor1, N Cheng, R W Williams

  • 1Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0830, USA.

Science (New York, N.Y.)
|February 26, 1999
PubMed
まとめ

酵母中の[URE3]プリオンは,Ure2pタンパク質のアミロイドフィラメントの自己拡散によって説明されます. これらのアミロイド構造は,Ure2pの断片によって形成され,ネイティブUre2pのポリメリゼーションを誘導し,プリオン行動を模倣することができます.

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Replication in Eukaryotes

Overview
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Nucleotide Excision Repair

Overview
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Initiation of Translation

Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
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Replication in Prokaryotes

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Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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Eukaryotic replication follows many of the same...
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Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...