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Updated: Jul 21, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

インターフェロン-ガンマ/STAT経路による変形成長因子β/SMAD信号伝達の阻害

L Ulloa1, J Doody, J Massagué

  • 1Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Nature
|March 6, 1999
PubMed
まとめ

インターフェロン-ガンマ (IFN-ガンマ) は,Smad7を誘導し,Smad3の活性化を阻害することによって,成長因子-β (TGF-β) 信号伝達の変換を阻害する. これはSTATとSMAD経路のクロストークを明らかにし,それらの敵対的な細胞効果を説明します.

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Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay11:38

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