若い女性および中年女性のインフルエンザ関連疾患および死亡率
K M Neuzil1, G W Reed, E F Mitchel
1Department of Medicine, University of Washington School of Medicine, and the Veterans Affairs Medical Center, Seattle, USA.
JAMA
|March 17, 1999
まとめ
慢性疾患を有する65歳未満の女性は,インフルエンザの重大なリスクに直面しています. 高リスクの女性を対象とした年次インフルエンザ予防接種は,入院や死亡を減らす上で極めて重要です.
科学分野:
- 公衆衛生は公衆衛生である.
- エピデミオロジー エピデミオロジー
- 感染症 感染症とは
背景:
- 65歳未満の成人のインフルエンザ関連入院および死亡に関するデータは限られている.
- これらのリスクを理解することは,標的を絞った公衆衛生の介入に不可欠です.
研究 の 目的:
- 65歳未満の女性におけるインフルエンザによる重篤な罹病率と死亡率を定量化する.
- HIVを含む慢性疾患がインフルエンザ関連のアウトカムに与える影響を評価する.
主な方法:
- テネシー州メディケイド (1974年-1993年) に登録された15歳から64歳までの女性に関する遡及的なコホート研究.
- インフルエンザシーズンにおける急性心肺疾患による入院と死亡を分析した.
- 季節間の発生率を比較することによって,インフルエンザに起因するリスクの計算.
主要な成果:
- インフルエンザシーズン中に急性心肺疾患の発生率が一貫して高い.
- 高リスクの女性では,過剰な年間イベントは1万人に23-58件 (入院/死亡),1万人に2件 (死亡) であった.
- 高リスク状態のない女性では,過剰なイベントが少ない (10,000人に4〜6件).
結論:
- 慢性疾患を有する65歳未満の女性は,インフルエンザによる実質的な罹病率と死亡率を経験します.
- これらの高リスク集団をターゲットとした強化されたインフルエンザ予防接種戦略は正当化されています.
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