ヒポプタラム性ゴナドトロピンを放出するホルモンの継続的および中断的な投与に対する下肉体の反応
まとめ
断続的なゴナドトロピン放出ホルモン (GnRH) 投与は,連続注入とは異なり,サルでは下垂体機能を回復させます. これは,持続的なホルモン放出と無感化を回避するために,パルス性のGnRH投与の重要性を強調しています.
科学分野:
- 生殖内分泌学 生殖内分泌学
- 神経内分泌学の神経内分泌学
- 霊長類の生理学について
背景:
- 視床下部病変は,下垂体性ゴナドトロピンの分泌を廃止する.
- ゴナドトロピンを放出するホルモン (GnRH) の継続的な注入は,分泌の回復に失敗する.
研究 の 目的:
- 断続的なGnRH投与と継続的なGnRH投与が,下垂体病変を有する rhesus猿のゴナドトロピン分泌に及ぼす影響を調査する.
- GnRHの配給パターンが下垂体反応に影響するかどうかを判断する.
主な方法:
- レサス猿における下垂体病変の誘導により,内在的なGnRH.を廃止する.
- 外因的なGnRHの投与は,連続注入または断続的な (毎時間) パルスによるものです.
- 異なるGnRH配給パターンに対する反応として,下垂体ゴナドトロピン分泌のモニタリング.
主要な成果:
- 断続的なGnRH投与 (時1回) は,持続的な下垂体ゴナドトロピンの分泌を回復させた.
- 継続的なGnRH注入は,ゴナドトロピンの分泌を回復することができなかった.
- 断続的な復元後のGnRHの継続的な投与は,無感化/下調につながった.
結論:
- 生理学的周波数を模倣する脈動性GnRH投与は,下垂体ゴナドトロピン分泌の回復と維持に不可欠です.
- 量だけでなく,GnRH投与のパターンが,下垂体反応率を決定する.
- 継続的なGnRHは,下垂体腺の無感化につながる可能性があります.
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